On Wednesday, researchers unveiled in Nature a significant improvement — a new CRISPR system that can switch single letters of the genome cleanly and efficiently, in a way that they say could reliably repair many disease-causing mutations.
https://www.statnews.com/2016/04/20/clever-crispr-advance-unveiled/
Harvard University biochemist David Liu and post-doctoral fellow Alexis Komor, who led the work, have filed a provisional patent application on their invention, which changes one-letter misspellings in DNA called point mutations. Liu is a consultant to and cofounder of Editas Medicine, a genome-editing company in Cambridge, Mass., that went public in February. Church is also a cofounder of Editas.
“Most known human genetic variations associated with disease are point mutations,” said Liu. “Current gene-editing methods aren’t particularly good at correcting those.”
The problem addressed by the new technique is not the usual one discussed with CRISPR, namely, off-target effects. That refers to changing a region of the genome other than the intended one. While early genome-editing experiments had that problem, there has been “tremendous progress” in fixing it, said Dr. Keith Joung of Massachusetts General Hospital.
Neat
>>71596053
>hex editing your DNA
Give me infinite health mother fuckers
>mfw we're heading for the Eugenics Wars from Star Trek
>>71596053
For fuck sake this is officially spam stop shitposting this topic every fucking day.
>>71596053
Its fucking nothing.
>He still thinks we aren't capable of cloning humans.
>>71596204
Soon
Better than Cas9
>>71596204
That's DNA breaking down over time. You can slow it down by eating well and exercise.
Gum disease also speeds up DNA breaking down also. So brushing your teeth twice a day might prolong your life more then any other activity.
>>71596278
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature17946.html
It's not spam, it's a fucking published paper you dumb piece of shit.
Because the new version of CRISPR avoids that mess, it “offers a huge step forward,” said Church, who was not involved in the discovery, and whose 2013 paper helped launch the CRISPR frenzy. “It is arguably the most clever CRISPR gadget to date.”
"Huge step Forward"
>>71596209
That was the Clone Wars and it's from Star Wars, not Star Trek. Do you even sci-fi?
Literally the only thing I would use this for would be to ensure desired hair and eye colour.
It's an affront to God to start changing who your children are.
Often it is the ailments a person has that spurs them to greatness.
>>71596584
https://en.wikipedia.org/wiki/Timeline_of_Star_Trek#Eugenics_Wars_and_World_War_III
>>71596663
This girl pictured is dying of an incurable genetic disease.
You are saying, "Don't cure her, let her die, because that's what drives people to greatness."
So if you get a bad infection, let's not administer antibiotics and let it kill you.
>>71596856
strawman nig
come back with an argument
>>71596209
KHAAAAAAAAAN
>>71596373
>"Huge step Forward"
Gonna be yuuuuuge!
>>71596945
your a dumb a nigger and your children will die because you failed to vaccinate them.
>>71597383
completely unrelated to my earlier post
>>71596856
She receives treatment and it cures her illness but there is one side effect. She is now a psychotic killer and murders her entire family and blows up her school. You just made a new queen of /b. Dumbass.
>>71596325
If Straya says it, you must do the opposite. Never brushing again. Never did anyway
>>71597674
retard
She gets treatment, turns into a ninja, and teleports behind you with a sword.
>my fantasy scenarios really fucking matter.
>>71597982
>She gets treatment, turns into a ninja, and teleports behind you with a sword.
Nothing personnel
>baldness will be cured in your lifetime
Smooth sailing for humanity from now on? Right?
>>71598018
Here is how I argue
I'll make up a random scenario. This scenario will be really bad, and then I say, "What if X happens."
Look, what if you raise taxes 1% and everyone decides they'd rather not work. Then everyone becomes suicidal and everyone kills themself.
So of course you can't ever raise taxes.
THIS IS HOW YOU FAGGOTS ARGUE
This is a picture of a deceased child who died of a genetic disease.
>>71597982
Damn that is creepy and hot all at the same time. What is it about Asian women where they look sweet but you can tell they are plotting to rip your throat out at the first available opportunity?
>>71598305
Do you have any deceased by other means? Do you have a collection to share maybe?
>>71596325
Gum disease speeds up DNA breaking down everywhere? Or just in your gums? Sorry if that's a stupid question.
I'm interested in learning more. Are you a dentist?
>>71598305
>>71598654
Makes your teeth fall out, you starve and die. You can't fight off disease if you are malnourished. You will however make more money sucking dick.
>>71596663
I suppose when IQ-enhancing gene-editing comes out, you won't buy any, right?
>>71596053
Oh god is that a trap? If so I'm gay
>>71598463
Nearly black irises hide pupil dilation and make people difficult to read.
>>71596325
Not quite. That's a bit oversimplified. The only real instance of DNA breakdown is the gradual reduction in telomere length over time. This is treatable with telomerase, a protein that your body already produces.
>>71599478
that results in cancer for the vast majority of people.
>>71598118
What
>tfw when you were born too late to get the Icelandic genetic variation that makes you super resistant to alzheimers crispred into your genes
>>71596053
god emperor trump ruling for 300 years confirmed
>>71596053
Non bitchy women without cellulite.. when?
>>71596053
>Because of “the cell’s desperate attempts” to mend its genome, said Harvard University biologist George Church, “what often passes as ‘genome editing’ would more appropriately be called ‘genome vandalism,’” as the cell inserts and deletes random bits of DNA where CRISPR cuts it.
They make it sound as if they're committing acts of torture at just about the tiniest scales physically possible with regard to the edited cells. I'm all for the radical life extension this might bring about though; I can't wait for Alphabet (via Calico) to buy in and offer "free" crazy life extension plans in exchange for you signing away the literal entirety of your privacy lel.
>>71596053
>Because of “the cell’s desperate attempts” to mend its genome, said Harvard University biologist George Church, “what often passes as ‘genome editing’ would more appropriately be called ‘genome vandalism,’” as the cell inserts and deletes random bits of DNA where CRISPR cuts it.
>“Having these random insertions or deletions is unhelpful,” Liu said.
Unless your goal is to make an army of autistic mutants with retard strength, this doesn't seem too promising for now.
>Genetic engineering is perfected in a few years while Trump, Farage, Putin, Wilders, Le Pen, Abe and the chinks are in power
Get ready for the golden age of perfectly engineered mankind, gentlemen.
>>71600928
stopping cellulite makes the skin less soft.
You would be more turned off by their skin looking "harder" and dry like a males generally.
>>71601336
>mfw born in the last generation of mortals
>>71601452
It can edit living cells, anon.
>>71601607
Yeah but the chance someone born in 2040 gets to live forever is probably like 100000x our chance.
Not that either are extraordinarily high.
Tried this with Cas9 in HEK293 cells. Think in our whole lab 1 person got 1 of their clones to successfully repair. Hopefully this works better or at least in a different cell line.
>>71602003
It's getting better at a scary pace.
>>71601425
That's what fembots and genetic engineering is for then. Less cellulite, more soft.
>>71596663
We God Now Weedy.
>DNA modify mental capacity of a nigger
>turns white
Does anyone have any pictures from this girl's Instagram?
I really want more.
>>71596945
come back with a gunshot would
>>71601452
WE
WUZ
BORN
TO
BE
KANGS
>>71604237
>>71601190
>Not reading that the whole point of the article was that they found out how to change a single letter in the DNA, which avoids the cell freaking out as a result of the current way they've been deleting/adding bits of DNA.
>>71599818
Which is why brushing teeth is so important.
