Sci,
Can you tell me about the human immune system and autoimmune diseases.
Specifically how TH1, TH2 and TH17 cells work, how they are created and regulated and what epigenetic triggers cause these different cells/systems to be produced.
Also will taking diindolylmethane fix my autoimmune issues, like massive food intolerances I've developed over the past 10 years?
Thanks
:^)
Why does /sci/ hate biology?
>>8166510
because biologists tell us that 2 identical looking dogs who can mate are from different spiece when 1 human and 1 ape from Africa is the same.
>>8166510
Because when we start to take interest in biology we wind up on gif
>>8166510
Because when we start to take interest in biology we end up on gif
>>8166463
I am sorry to say this, but I can't cover the whole story on a board like that. The immune system is an enormous, misunderstood, complex machine.
About T cells : Their "creation" (better use the term differentiation) merit a whole chapter, but basically : TH1,2,3,9,17,reg, etc... come from CD4+ T cells, present in lymph nodes.
When activated by an APC (antigen presenting cell, like dendritic cells, B cells) they proliferate and differentiate into a specific subtype depending of the immune context. What I mean by that ? Mainly cytokines. When activating a T cell, the APC also produces specific cytokines, each combination guide T cell differentiation.
Pic related, it's a simple yet good representation of cytokines and transcription factors involved in this process.
>>8166608
Would DIM be able to change how these cells work and stop my autoimmune food allergies?
>>8166623
No, it's a very weak immunostimulant and have nothing to do with autoimmunity or allergies (both different things).
>>8166655
What is it being used for?
I heard it lifts epigenetic NRF2 blocks and does something to change TH1/2/17 cells.
>>8166701
3,3'-diindolylméthane, right ? Or even diindolylméthane ? If it's this, then I don't see a single paper linking it to what you are saying.
Do you have some source we can work with ?
>>8166708
https://youtu.be/waZAH8sEWa0?t=1h45m10s
This.
This guy is a Phd and talks about ways to upregulate certain genes to detoxify mercury.
Which I have a lot of in my body.
How exactly would DIM shift from T17 back to normal?
>>8166760
The guy himself didn't publish anything about it, but there is some papers about immunoregulatory indols. Thanks.
Can't say for sure, for what I see it seems DIM activates some part of the immune system and inhibits others. DIM activated Treg, that shut down Th17 activity and differentiation.
>>8166776
>The guy himself didn't publish anything about it,
He was referring to a paper published about it. I can't find that paper though.
This talk was like 2 weeks ago or something.
>Can't say for sure, for what I see it seems DIM activates some part of the immune system and inhibits others. DIM activated Treg, that shut down Th17 activity and differentiation.
Okay, I'm still retarded on this biology stuff.
But do you think if my immune system is fucked up from mercury toxicity, taking will will fix my immune system?
>>8166776
This is the paper I think.
![maxresdefault[1].jpg](https://i.imgur.com/nNPBn1w.jpg "maxresdefault[1]")
