Is it better to read the Discworld books in release order, or in one of the several different convoluted orders that fans of the series suggest?
You should probably read any of the series focused on individual characters in that order but which one you choose isn't all that important.
I'd go Rincewind - Death - Witches - Watch - Lipwig, skip the science and read the others whenever. Presumably you're not going to sit down and read them all sequentially anyway.